Protic pyridinium ionic liquid: As an efficient, green and environmentally friendly catalyst for the one-pot synthesis of amidoalkyl naphthol derivatives

A green and efficient synthesis of amidoalkyl naphthol derivatives via the three-component reaction between aryl aldehyde, 2-naphthol and amide derivatives using 2-methylpyridinium trifluoromethanesulfonate ([2-MPyH]OTf) as a catalyst (5 mol%) is described. This method provides several advantages over alternative procedures such as low cost, under thermal solvent-free green procedure, simple procedure and direct isolation of the products in high yields.

Graphical abstractAmidoalkyl naphthol derivatives were synthesized using [2-MPyH]OTf as an ionic liquid catalyst under thermal solvent-free condition.Figure optionsDownload full-size imageDownload as PowerPoint slide