| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 170571 | Comptes Rendus Chimie | 2014 | 6 Pages |
Abstract
Collagen sponges are known to be safe and well-characterized supports for drug delivery systems. The aim of this study was to prepare, characterize and test drug delivery systems that contain collagen as support and niflumic acid as a drug. Type-I collagen and niflumic acid gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices (spongious form). The physical-chemical properties were assessed by infrared spectroscopy (FTIR) and morphological properties were evaluated by water absorption. Niflumic acid release from cross-linked collagen spongious forms was also investigated and the kinetic mechanism was discussed.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Răzvan Constantin Barbaresso, Ileana Rău, Roxana Gabriela Zgârian, Aurelia Meghea, Mihaela Violeta Ghica,