A sustainable approach to the Ugi reaction in deep eutectic solvent

The Ugi reaction goes fast with high yields in a recyclable and biodegradable low-melting mixture of choline chloride and urea (DES) as a novel and efficient reaction medium. The DES is applicable to a wide range of aldehydes, amines, isocyanides, and acids in good to excellent isolated yields (60–92%) and short reaction times (2–5 h) and can be reused four times without any loss of activity.

Graphical abstractUgi reaction goes fast with high yields in a recyclable and biodegradable low-melting mixture of choline chloride–urea as a novel and efficient reaction medium.Figure optionsDownload full-size imageDownload as PowerPoint slide