An efficient and green method for the synthesis of [1,3]oxazine derivatives catalyzed by thiamine hydrochloride (VB1) in water

An efficient and convenient synthesis of 1,3-oxazine derivatives has been achieved by the one-pot, multicomponent condensation of α- or β-naphthol, an aniline and formaldehyde using thiamine hydrochloride (VB1) as a versatile biodegradable and reusable catalyst in water as a universal solvent.

Graphical abstractAn efficient and convenient synthesis of 1,3-oxazine derivatives using VB1 as a versatile biodegradable catalyst in water.Figure optionsDownload full-size imageDownload as PowerPoint slide