Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
171242 | Comptes Rendus Chimie | 2011 | 9 Pages |
Abstract
An efficient and novel synthesis of 2,3-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via one-pot, three-component reaction of isatoic anhydride, primary amines and aromatic aldehydes catalyzed by Bi(NO3)3·5H2O under solvent-free conditions is described. Oxidation of these 2,3-dihydroquinazolin-4(1H)-ones to their quinazolin-4(3H)-ones was also successfully performed in the presence of Bi(NO3)3·5H2O. This new method has the advantages of convenient manipulation, short reaction times, excellent yields, very easy work-up, and the use of commercially available, low cost and relatively non-toxic catalyst. The role of Bi(NO3)3·5H2O was also investigated in these transformations.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Iraj Mohammadpoor-Baltork, Ahmad R. Khosropour, Majid Moghadam, Shahram Tangestaninejad, Valiollah Mirkhani, Saeid Baghersad, Arsalan Mirjafari,