| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1716820 | Acta Astronautica | 2008 | 5 Pages |
Abstract
Pharmacological norepinephrine transporter (NET) inhibition improves orthostatic tolerance on a tilt table while increasing heart rate. We tested the cardiovascular response to NET inhibition during a graded human centrifuge run in seven healthy men. g-Load was increased in 0.5Â g steps with 3Â g maximal g-load. On two separate days, patients were tested after selective NET inhibition with reboxetine or with placebo in a double-blind, randomized, crossover fashion. Resting diastolic blood pressure increased moderately with NET inhibition. Resting heart rate was profoundly increased by NET inhibition. NET inhibition augmented the heart rate response while attenuating the increase in blood pressure during hypergravitation. NET inhibition could be tested for its potential to improve cardiovascular g-tolerance.
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Authors
Christoph Schroeder, Sebastian Strempel, Andrea Boese, Ruth Hemmersbach, Jens Tank, Friedrich C Luft, Jens Jordan,