Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1717217 | Acta Astronautica | 2006 | 10 Pages |
Abstract
Male and female mice were subjected to rotationally-generated hypergravity of different duration (1 or 2Â h) and linear acceleration (2 or 1.08Â G). Pica behaviour and spontaneous activity were investigated before, during, and after rotation. Moreover, hole-board and plus-maze tests were performed 20Â min and 24Â h after the end of rotation. Pica behaviour arose in the post-rotation days and was more pronounced after 1Â h of 2Â G exposure. Spontaneous activity was almost or totally suppressed during rotation and failed to regain the pre-rotational levels in the group exposed to 2Â G for 1Â h. Exploratory behaviour in the hole-board was also impaired. A clear effect of hypergravity exposure emerged in the plus maze, with 2Â G mice totalizing a minor number of arm entries than the other groups and also showing an altered emotional/anxiety profile. Generally, females were more susceptible than males to the changes in gravitational environment.
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Authors
N. Francia, G. Corazzi, S. Petruzzi, D. Santucci, E. Alleva,