Article ID Journal Published Year Pages File Type
173512 Computers & Chemical Engineering 2008 6 Pages PDF
Abstract

In this article we address the steady state design of a nonlinear tryptophan biosynthesis model with guaranteed stability of the optimal solution in the presence of parametric uncertainty. The optimization based approach – denoted constructive nonlinear dynamics (CNLD) – is based on constraints that enforce a minimal distance in the space of the uncertain parameters between a stability boundary and the optimal solution. The results obtained with CNLD are compared to results recently presented by Chang and Sahinidis [Chang, Y. J., & Sahinidis, N. V. (2005). Optimization of metabolic pathways under stability considerations. Computers and Chemical Engineering, 29 (3), 467–479], where the optimization of the tryptophan biosynthesis model was addressed by a global optimization algorithm. CNLD takes the nonlinearities of the process exactly into account and satisfies the specified robustness criteria without being overly conservative.

Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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