Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
173997 | Computers & Chemical Engineering | 2008 | 14 Pages |
Abstract
The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method for identifying coherent and informative expression motifs and we subsequently determine conserved transcription factor binding sites for the sub-sets of co-expressed genes. The responses are rationalized in the context of burn-induced inflammation and the putative transcription factors are rationalized in the context of intervention targets for controlling gene expression.
Keywords
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Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
E. Yang, T.J. Maguire, M.L. Yarmush, F. Berthiaume, I.P. Androulakis,