| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 174540 | Current Opinion in Chemical Engineering | 2013 | 7 Pages |
To improve safety and efficacy of anti-cancer therapy, drug-loaded polymeric nanoparticle micelle systems have been designed to target tumour pathophysiology. To accomplish this, nanoparticles take advantage of enhanced permeability and retention (EPR) of macromolecules to target tumours on a tissue level (passive targeting) while conjugated targeting ligands bind cancer surface markers and promote nanoparticle uptake (active targeting). Composition, size, shape, drug loading, and ligand density are all tunable design parameters that impact nanoparticle targeting. Understanding the complex interplay between these parameters and the resulting effects on drug targeting rationalizes adjustments to nanoparticle formulations.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Nanoparticle design parameters impact drug transport to tumours in complex ways. ► Long circulation enables accumulation but reduces contrast against healthy tissue. ► Larger sized nanoparticles boost drug loading but reduces tumour penetration. ► Spherical shaped nanoparticles have shorter circulation but more rapid uptake than rod shaped. ► Targeting ligands enhance uptake but impede penetration beyond vascular periphery.
