| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 175429 | Dyes and Pigments | 2016 | 6 Pages |
•A NIR sensor was developed to display the Cu2+-specific emission quenching effect.•The in vivo fluorescent Cu2+ imaging in live mice was realized for the first time.•The large Stokes shift reduces the sensor self-absorption, favoring in vivo imaging.•The sensor displays the minor photobleaching interference in imaging.•The intramolecular CT effect in sensor is essential for its in vivo imaging behavior.
Modifying the BODIPY fluorophore with a 4-aminostyryl group forms a NIR fluorescent Cu2+ sensor with a large Stokes shift, high photostability and a high quantum yield. The in vivo Cu2+ fluorescence imaging in live mice was realized for the first time with this sensor, profiting from its reduced self-absorption and minor photobleaching.
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