| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 175602 | Dyes and Pigments | 2016 | 8 Pages |
Abstract
•Extended rigid rhodamines were designed via molecular simulations.•The trend of spectral properties of rhodamines agreed with TDDFT calculations.•Amine-reactive probes for bioconjugation were synthesized.•To be used as molecular ruler to study pore dilation in cationic channels.
A series of geometrically well-defined cationic fluorophores were designed based on molecular mechanics. They contain biaryl linkers to impart rigidity preventing intramolecular folding between a conjugated biomolecule and fluorophore. All probes have absorption and emission maxima within 20 nm from Texas Red, as predicted by TDDFT calculations and validated experimentally.
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Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Yu-Hsuan Chu, Jorge O. Escobedo, Meiyan Jiang, Peter S. Steyger, Robert M. Strongin,