| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 175878 | Dyes and Pigments | 2015 | 8 Pages |
•A new series of methine cyanine dyes have been prepared for use as dyestuffs.•Carbocyanine dyes caused a battfhochromic and/or hypothochromic shift.•Heptamethine cyanine dye caused a bathochromic shift.•All the synthesized compounds were subjected to in vitro anticancer screening.•The most active compound 3 showed selective influence on cervical cancer cell lines.
We report the synthesis of new series of methine cyanine dyes 1, 3–13which have been obtained by the one-pot step reaction of quaternized heterocyclic compound 2 with benzenaminium salt 1 under various methodology technique. (E)-N-(((E)-2-Chloro-3-((phenylamino)methylene)cyclopent-1-enyl)methylene) benzenaminium chloride (1) was synthesized by the reaction of cyclopentanone with Vilsmeier-Haack reagent, then a mixture of an equimolar ratio of aniline: ethanol (1:1) was added to give the target compound. All the synthesized compounds were subjected to in vitro anticancer screening against two cell lines, human cervix carcinoma cell line and human breast carcinoma cell line. Some of these compounds were found to be equipotent or more potentthan commercial anticancer as an evident from the results.
Graphical abstractA new series of methine cyanine dyes 1, 3–13 have been prepared. The electronic spectra of carbocyanine dyes 1, 3–13 underwent a bathochromic and/or hypothochromic shift. Compound 8 caused a bathochromic shift.Figure optionsDownload full-size imageDownload as PowerPoint slide
