| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1759029 | Ultrasonics | 2012 | 6 Pages |
Abstract
⺠Lactone-formed 10-hydroxycamptothecin (HCPT) loaded PLA microbubbles were fabricated by a double emulsion-solvent evaporation method. ⺠The HCPT loaded PLA microbubbles had the typical characteristics of drug carrier, and possessed ultrasound-triggered drug release mechanism. ⺠The HCPT loaded PLA microbubbles combined with ultrasound exposure showed more cytotoxic than the microbubbles alone. ⺠The combination of drug loaded microbubbles and diagnostic ultrasound exposure exhibit an effective intracellular drug uptake by tumor cells, indicating their great potential for antitumor therapy.
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Authors
Zhenqing Hou, Le Li, Chuanming Zhan, Peijuan Zhu, Di Chang, Qiwei Jiang, Shefang Ye, Xiangrui Yang, Yang Li, Liya Xie, Qiqing Zhang,