Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1760142 | Ultrasound in Medicine & Biology | 2016 | 10 Pages |
Abstract
The purpose of this study was to determine the effects of different therapeutic 1-MHz ultrasound waveforms on endothelial function before and after cyclooxygenase (COX) inhibition. Forty-two healthy volunteers aged 27.2 ± 3.8 y underwent interventions and an evaluation for endothelial function (n = 15; with COX inhibition, n = 15; duration of the vasodilator effect, n = 12) by technique flow-mediated dilation. Continuous ultrasound therapy (0.4 W/cm2 SATA), pulsed ultrasound therapy (20% duty cycle, 0.08 W/cm2 SATA) or placebo (equipment power off) was randomly applied over the brachial artery for 5 min. COX inhibition (aspirin) was carried out 30 min before treatments. In relation to the placebo, flow-mediated dilation increased by 4.8% using continuous ultrasound and by 3.4% using pulsed ultrasound. After COX, flow-mediated dilation was enhanced by 2.1% by continuous ultrasound and 2.6% by pulsed ultrasound. This vasodilation persisted for 20 min. Continuous and pulsed therapeutic 1-MHz ultrasound waveforms improved endothelial function in humans, which provided them with anti-inflammatory vascular effects.
Keywords
Related Topics
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Authors
Jeferson Mendes Cruz, Melina Hauck, Ana Paula Cardoso Pereira, Maicon Borges Moraes, Cassio Noronha Martins, Felipe da Silva Paulitsch, Rodrigo Della Méa Plentz, William Peres, Antônio Marcos Vargas da Silva, Luis Ulisses Signori,