Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1762606 | Ultrasound in Medicine & Biology | 2007 | 13 Pages |
Abstract
High frequency ultrasound imaging (20 to 60 MHz) is increasingly being used in small animal imaging, molecular imaging and for the detection of structural changes during cell and tissue death. Ultrasonic tissue characterization techniques were used to measure the speed of sound, attenuation coefficient and integrated backscatter coefficient for (a) acute myeloid leukemia cells and corresponding isolated nuclei, (b) human epithelial kidney cells and corresponding isolated nuclei, (c) multinucleated human epithelial kidney cells and d) human breast cancer cells. The speed of sound for cells varied from 1522 to 1535 m/s, while values for nuclei were lower, ranging from 1493 to 1514 m/s. The attenuation coefficient slopes ranged from 0.0798 to 0.1073 dB mmâ1 MHzâ1 for cells and 0.0408 to 0.0530 dB mmâ1 MHzâ1 for nuclei. Integrated backscatter coefficient values for cells and isolated nuclei showed much greater variation and increased from 1.71 Ã 10â4 Srâ1 mmâ1 for the smallest nuclei to 26.47 Ã 10â4 Srâ1 mmâ1 for the cells with the largest nuclei. The findings suggest that integrated backscatter coefficient values, but not attenuation or speed of sound, are correlated with the size of the nuclei. (E-mail: [email protected])
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Linda R. Taggart, Ralph E. Baddour, Anoja Giles, Gregory J. Czarnota, Michael C. Kolios,