| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 176327 | Dyes and Pigments | 2014 | 6 Pages |
•A new turn-on colorimetric and fluorescent probe has been synthesized.•The probe exhibits highly sensitivity and selectivity toward the biothiols.•The probe features fast signal response and excitation in the visible region.•Fluorescence imaging of cells for thiols in vivo was carried out successfully.
A new highly sensitive 1, 8-naphthalimide-based compound (probe 1) has been designed and synthesized. The colorimetric and fluorescent properties of probe 1 towards various amino acids were investigated in detail. Specific colorimetry and fluorescence response of probe 1 for thiols were found in PBS buffer solution, which can be deduced to a reaction of thio-promoted conjugate addition/cyclization sequence between probe 1 and thiols. The probe 1 can selectively recognize cysteine rather than other natural amino acids in aqueous solution with a rapid response time. Con-focal fluorescence imaging of cells for detecting thiols in vivo was carried out successfully.
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