| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 176477 | Dyes and Pigments | 2013 | 6 Pages |
•Two rhodamine-hydrazone derivative 1 and 2 bearing thiphene moiety were synthesized as selective fluorescent probes for Hg2+.•Probe 1 and 2 displayed highly selective fluorescence enhancements with Hg2+.•Probe 1 and 2 were sucessfully applied to image Hg2+ in the HeLa cell.
Rhodamine derivatives bearing the thiophene (1) and bisthiophene (2) groups are synthesized and their binding selectivity toward various metal ions was studied. The X-ray crystal structure of 1 was also reported. Probes 1 and 2 showed highly selective “Off–On” fluorescence changes with Hg2+ among various metal ions. These selective changes were attributed to the spirolactam ring opening processes and subsequent hydrolysis. Probes 1 and 2 were sucessfully applied to the cell-imaging of Hg2+ using HeLa cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
