Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
177529 | Dyes and Pigments | 2010 | 8 Pages |
Abstract
A series of asymmetric porphyrins with varying substituents, such as 4-hydrophenyl and N-methyl-4-pyridyl, were synthesized and characterized and their cell uptake, intracellular localization, cytotoxicities and phototoxicities were evaluated in vitro. The most phototoxic of the porphyrins synthesized, 5,10-di-(N-methyl-4-pyridyl)-15,20-(4-hydroxyphenyl)-21,23H-porphyrin, which was mainly localized in the mitochondria and displayed low levels of dark toxicity toward human cancer HeLa cells, offers potential application in photodynamic therapy.
Related Topics
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Authors
Cheng-Liang Peng, Ping-Shan Lai, Cheng-Chung Chang, Pei-Jen Lou, Ming-Jium Shieh,