Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
178279 | Dyes and Pigments | 2006 | 4 Pages |
Abstract
A rapid and sensitive spectrophotometric method is proposed for determination of Metronidazole and Secnidazole. The method depends on the reduction of Metronidazole and Secnidazole molecule with zinc dust and hydrochloric acid flowed by diazotization and coupling with β-naphtol to give red colored chromogens easily measured spectrophotometrically which has λmax = 510 nm. The experimental conditions were optimized and Berr's law was obeyed over the applicable concentration ranges. Both techniques were applied successfully to a wide variety of pharmaceutical preparations.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
T. Saffaj, M. Charrouf, A. Abourriche, Y. Aboud, A. Bennamara, M. Berrada,