Crystallization of the polymorphs of succinic acid via sublimation at different temperatures in the presence or absence of water and isopropanol vapor

α Succinic acid was prepared from the gas phase via the sublimation of the β form. Two sublimation methods including sublimation with carrier gas and sublimation in the presence of foreign molecules were employed. The influence of the sublimation temperature and the crystallization temperature on the polymorph and morphology are presented and discussed. At high supersaturation, the α polymorph predominated, and at low supersaturation the β polymorph was obtained. The influences of water and isopropanol in the gas phase on the morphology of β succinic acid grown via the sublimation are presented and compared with morphologies of crystals grown from solution.

► α Succinic acid was prepared via sublimation. ► The temperature influence on the polymorph and morphology is discussed. ► The influences of water or isopropanol vapor on the morphology are presented.