Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1792515 | Journal of Crystal Growth | 2010 | 12 Pages |
Abstract
This study focuses on ultrasound-assisted anti-solvent crystallization of lactose, expanding on previous studies and presenting, for the first time, the results of large scale implementation of sonocrystallization for lactose. The results further clarify the interplay between solution chemistry – namely the role of β-lactose – and crystallization, representing a step forward in the fine tuning of lactose properties for pharmaceutical manufacturing applications. Batches manufactured at laboratory and pilot scales were extensively characterised, including an approach for the quantification of β-lactose in α-lactose based on powder X-ray diffraction (PXRD), which is described here.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
E. Kougoulos, I. Marziano, P.R. Miller,