Optimal design of nanomagnets for targeted hyperthermia

We have numerically simulated the dynamic response of single-domain nanomagnets to alternating magnetic fields and discuss nanometer-sized thermal seeds suitable for selectively targeted magnetic hyperthermia. When we assign priority to the easy delivery and biological safety of these fields, the maximum heating power is obtained by the irradiation of a weak field at a medium frequency (∼1 MHz) on almost spherical magnetite nanomagnets with a diameter of approximately 20 nm. On the other hand, the irradiation of the amplified field at a low frequency (∼100 kHz) is more effective if the neural stimulation is allowable.

Research Highlights► Simulation of the dynamic response of single-domain nanomagnets. ► Exposure limits for alternating magnetic fields. ► Size- and shape-controlled magnetite nanomagnets. ► Optimal design for maximum specific energy absorption rate.