Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1802483 | Journal of Magnetism and Magnetic Materials | 2009 | 4 Pages |
Abstract
Magnetic nanoparticles have been investigated for biomedical applications for more than 30 years. The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is imminent in medical research, especially for treating cancer and vascular diseases. We used drug-labeled magnetic iron oxide nanoparticles, which were attracted to an experimental tumor in rabbits with an external magnetic field (magnetic drug targeting, MDT). Aim of this study was to detect and quantify the biodistribution of the magnetic nanoparticles by magnetorelaxometry. The study shows higher amount of nanoparticles in the tumor after intraarterial application and MDT compared to intravenous administration.
Related Topics
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Condensed Matter Physics
Authors
Rainer Tietze, Roland Jurgons, Stefan Lyer, Eveline Schreiber, Frank Wiekhorst, Dietmar Eberbeck, Heike Richter, Uwe Steinhoff, Lutz Trahms, Christoph Alexiou,