Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1802982 | Journal of Magnetism and Magnetic Materials | 2009 | 6 Pages |
Abstract
The aim of this study was to attach a model drug (naproxen) onto superparamagnetic iron oxide nanoparticles (SPION). First, SPION were coated with thin layer of silica that contained micropores. We demonstrated that such surface functionalization could be optimized by the use of citric acid which prevented SPION agglomeration during the procedure. HRTEM investigation showed a uniform 1–2-nm-thick silica coating around SPION. This coating did not affect significantly the magnetic properties of the SPION. Into the coated SPION we successfully incorporated about 30 wt% of naproxen. The latter was readily released after immersion into a testing solution. The composites could be interesting for potential use in diagnostics.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Uroš Maver, Marjan Bele, Darko Makovec, Stanislav Čampelj, Janko Jamnik, Miran Gaberšček,