Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1804176 | Journal of Magnetism and Magnetic Materials | 2007 | 5 Pages |
Abstract
A dextran-ferrite magnetic fluid was successfully tested as magnetic resonance imaging (MRI) contrast agent. The same magnetic fluid was then combined with Melphalan, a chemotherapeutic drug, and used for magnetohydrodynamic thermochemotherapy of different tumors. The placement of the tumors in an AC magnetic field led to hyperthermia at 46 °C for 30 min. In combination with tumor slime aspiration, a 30% regression of ∼130 mm3 non-metastatic P388 tumors in BDF1 mice was reached, together with a life span increase of 290%. The same procedure associated with cyclophosphamide treatment of ∼500 mm3 metastases tumor increased the animal's life span by 180%.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Nikolay A. Brusentsov, Tatiana N. Brusentsova, Elena Yu. Filinova, Nikolay Y. Jurchenko, Dmitry A. Kupriyanov, Yuri A. Pirogov, Andry I. Dubina, Maxim N. Shumskikh, Leonid I. Shumakov, Ekaterina N. Anashkina, Alexandr A. Shevelev, Andry A. Uchevatkin,