Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1804205 | Journal of Magnetism and Magnetic Materials | 2007 | 6 Pages |
Abstract
Magnetically responsive nanoparticles (MNPs) might be candidates for pro-drug formulations for intraperitoneal (i.p.) treatment of ovarian cancer. We conducted feasibility experiments in an i.p. human ovarian carcinoma xenograft model to determine whether MNPs can be effectively vectored within this environment. Our initial results based on magnetic resonance imaging (MRI) indicate that i.p.-injected â¼15Â nm magnetite-based MNPs can in fact migrate toward NdFeB magnets externally juxtaposed to the peritoneal cavity above the xenografts growing in the anterior abdominal wall. MNP localization to the tumor/peri-tumoral environment occurs. Further development of this MNP pro-drug strategy is underway.
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Condensed Matter Physics
Authors
Jim Klostergaard, James Bankson, Edmond Auzenne, Don Gibson, William Yuill, Charles E. Seeney,