Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1804209 | Journal of Magnetism and Magnetic Materials | 2007 | 4 Pages |
Abstract
In this work, we performed the synthesis and in vitro characterization of a new class of drug delivery system (DDS) denominated magnetic nanoemulsion (MNE). The association of colloidal nanoparticles with biocompatible magnetic fluids results in a new DDS for application in photodynamic therapy (PDT) and magnetic hyperthermia treatment. It works in a synergic manner with an expected enhancement in tumor damage after minimum drug doses, based on heat dissipation and/or light photosensitization. For this purpose, we investigated the permeation and retention in vitro model using Foscan® as a photosensitizer incorporated in MNE using a Franz diffusion cell and a biological skin model in biomimetic conditions.
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Authors
Fernando L. Primo, Leandro Michieleto, Marcilene A.M. Rodrigues, Patrícia P. Macaroff, Paulo C. Morais, Zulmira G.M. Lacava, Maria Vitória L.B. Bentley, Antonio C. Tedesco,