Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1804229 | Journal of Magnetism and Magnetic Materials | 2007 | 5 Pages |
Abstract
A new type of biosensor has been developed based on detection of nanosized superparamagnetic particles that serve as labels in bioreactions. The method is based on non-linear magnetic material detection by a magnetic field having components at two frequencies f1 and f2. The response is measured at the combinatorial frequencies fi=mf1+nf2, where m and n are integers, e.g., fi=f1±2f2. Several highly sensitive readers of superparamagnetic particles have been designed and used for development of various formats of immunoassays, including those compatible with immunoconcentration and magnetic enrichment of antigens.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Petr I. Nikitin, Petr M. Vetoshko, Tatiana I. Ksenevich,