Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1804231 | Journal of Magnetism and Magnetic Materials | 2007 | 6 Pages |
Abstract
This work investigated macrophages labeled with magnetosomes for the possible detection of inflammations by MR molecular imaging. Pure magnetosomes and macrophages containing magnetosomes were analyzed using a clinical 1.5 T MR-scanner. Relaxivities of magnetosomes and relaxation rates of cells containing magnetosomes were determined. Peritonitis was induced in two mice. T1, T2 and T2* weighted images were acquired following injection of the probes. Pure magnetosomes and labeled cells showed slight effects on T1, but strong effects on T2 and T2* images. Labeled macrophages were located with magnetic resonance imaging (MRI) in the colon area, thus demonstrating the feasibility of the proposed approach.
Related Topics
Physical Sciences and Engineering
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Condensed Matter Physics
Authors
Annegret Hartung, Marcus R. Lisy, Karl-Heinz Herrmann, Ingrid Hilger, Dirk Schüler, Claus Lang, Matthias E. Bellemann, Werner A. Kaiser, Jürgen R. Reichenbach,