The effect of hydrogen bond breaking defect on charge transport in a DNA molecular device

The charge transport in a DNA molecular device is theoretically investigated based on the Lattice Green Function method and Landauer-Büttiker theory. The effect of a hydrogen bond defect at different sites is investigated. A defect at the end of the DNA molecule reduces the current through the molecule, but a defect in the middle region of the molecule will have relatively slight effect on the current through the molecule. The effect of defect on the wave function distribution at the ends of the DNA molecule plays an important role in the defect mediated transport properties.