Denaturated proteins: Draining effect and molecular dimensions

Using equations derived from the synthetic macromolecules, we calculate the dimensions in solution of the denaturated proteins. For these calculations, we use a value for the Flory's parameter Φ obtained from an equation established for the polymers presenting a draining effect, and which is lower than the value of 2.6×1023 (cgs) generally used. The obtained values for the dimensions of the denaturated proteins (end to end distance, statistical segment length and relation from the end to end distance and the number of residue) using the method proposed here are in good agreement with the values obtained from Flory and co-workers. On the contrary, the values obtained in this work are different from the values proposed by other authors who do not take into account the draining effect and use a value for Φ equal to 2.6×1023.