SQUID-based systems for co-registration of ultra-low field nuclear magnetic resonance images and magnetoencephalography

The ability to perform magnetic resonance imaging (MRI) in ultra-low magnetic fields (ULF) of ∼100 μT, using superconducting quantum interference device (SQUID) detection, has enabled a new class of magnetoencephalography (MEG) instrumentation capable of recording both anatomical (via the ULF MRI) and functional (biomagnetic) information about the brain. The combined ULF MRI/MEG instrument allows both structural and functional information to be co-registered to a single coordinate system and acquired in a single device. In this paper we discuss the considerations and challenges required to develop a combined ULF MRI/MEG device, including pulse sequence development, magnetic field generation, SQUID operation in an environment of pulsed pre-polarization, and optimization of pick-up coil geometries for MRI in different noise environments. We also discuss the design of a “hybrid” ULF MRI/MEG system under development in our laboratory that uses SQUID pick-up coils separately optimized for MEG and ULF MRI.

► Co-registration of magnetoencephalography and ultra-low field MRI. ► Description of the design of a hybrid system. ► Optimization of pick-up coils for ultra-low field MRI. ► Suppression of switching transients by a 2nd feedback. ► Development of a clinically relevant multi-channel MEG/ULF MRI system.