Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1827155 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | 2010 | 5 Pages |
Abstract
Micro-proton-induced X-ray emission (μ-PIXE) analysis has been employed in investigating the presence of number of essential anions and cations in thin sections of diseased human articular cartilage affected by osteoarthritis (OA). Distribution maps for Ca, P, K and S in diseased sections show marked alterations in the concentrations of these at the bone–cartilage interface compared to normal tissue. For a decalcified section of human articular cartilage, organisational changes of the collagen network were investigated by small-angle X-ray scattering (SAXS). The established gradual reorientation of collagen fibres from vertical to the surface of the joint to normal to the bone–cartilage interface is observed to be heavily disrupted in OA.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Instrumentation
Authors
W. Kaabar, A. laklouk, O. Bunk, M. Baily, M.J. Farquharson, David Bradley,