Article ID Journal Published Year Pages File Type
1827885 Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 2009 4 Pages PDF
Abstract

The potential of incorporating three-quanta annihilation into positron emission tomography (PET) to detect local tissue chemistry was investigated using the GAMMASPHERE facility, which features a spherical array of 110 Compton-suppressed high-purity germanium (HPGe) detectors. Fluoro-2-deoxyglucose (FDG) containing F18 was introduced into 11 samples of haemolysed blood, serum, cell concentrate and whole blood, some of which had been either oxygenated or deoxygenated. The relative three-quanta yield was estimated from the reduced counts in the full-energy photopeak at 511 keV. Compton-suppression produced larger effects in the calculations than time-gating, suggesting its importance for this method of estimation. The relative three-quanta yields were found to vary as much as 11% between the samples. This level of sensitivity to different biological samples commends three-quanta annihilation for molecular imaging.

Related Topics
Physical Sciences and Engineering Physics and Astronomy Instrumentation
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