| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1831174 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | 2006 | 4 Pages |
Abstract
We have developed a photon-counting High-temporal and High-spatial resolution, High-throughput 3-Dimensional detector (H33D) for biological imaging of fluorescent samples. The design is based on a 25 mm diameter S20 photocathode followed by a 3-microchannel plate stack, and a cross-delay line anode. We describe the bench performance of the H33D detector, as well as preliminary imaging results obtained with fluorescent beads, quantum dots and live cells and discuss applications of future generation detectors for single-molecule imaging and high-throughput study of biomolecular interactions.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Instrumentation
Authors
X. Michalet, O.H.W. Siegmund, J.V. Vallerga, P. Jelinsky, J.E. Millaud, S. Weiss,