Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1831260 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | 2007 | 4 Pages |
Abstract
A mouse sized camera has been built in terms of collaboration between the presenting institutions. The system is used for the performance of dynamic studies in small animals, in order to evaluate novel radiopharmaceuticals. The active area of the detector is approximately 48Ã96Â mm allowing depiction of the entire mouse in a single view. The system is based on two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT), a pixellated NaI(Tl) scintillator and a copper-beryllium (CuBe) parallel-hole collimator. In this work, the evaluation results of the system are presented, using phantoms and small animals injected with conventional radiophrmaceuticals. Average resolution was â¼1.6Â mm on the collimator surface and increased to â¼4.1Â mm in 12Â cm distance from the detector. The average energy resolution was measured and found to be â¼15.6% for Tc99m. Results from imaging thin capillaries demonstrated system's high resolution and sensitivity in activity variations was shown. Initial dynamic studies have been carried out in small animals injected with Tc99m-DTPA and Tc99m-MDP. The results show system's ability to perform kinetic imaging in small animals.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Instrumentation
Authors
George Loudos, Stan Majewski, Randy Wojcik, Andrew Weisenberger, Nicolas Sakellios, Konstantina Nikita, Nikolaos Uzunoglu, Penelope Bouziotis, Alexandra Varvarigou,