Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1875845 | Applied Radiation and Isotopes | 2015 | 6 Pages |
Abstract
•Good yields and specific activity of [11C]PIB were obtained by reaction parameters optimization.•Improvement of the HPLC purification.•Quality parameters and drug formulation allows a readily application in clinic.
[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.
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Authors
A. Coliva, C. Monterisi, A. Apollaro, D. Gatti, M. Penso, L. Gianolli, D. Perani, M.C. Gilardi, A. Carpinelli,