| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1875853 | Applied Radiation and Isotopes | 2014 | 4 Pages |
•This study is clinical trials of BNCT for head and neck cancers.•BNCT was performed in 20 advanced/recurrent head and neck cancer patients.•The effective rate [(CR+PR)/total cases] was 90%.•BNCT is effective the patients with radio resistance head and neck cancer.•BNCT is a potential curative therapy for patients with head and neck cancer.
The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC.
