Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1875872 | Applied Radiation and Isotopes | 2014 | 5 Pages |
•We performed experimental boron biodistribution studies for lung metastases.•3 protocols employing BPA and GB-10 would be therapeutically useful.•BNCT at RA-3 would be potentially therapeutic for experimental lung metastases.
BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.