| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1875947 | Applied Radiation and Isotopes | 2014 | 5 Pages |
Abstract
The anti CD20 antibody Rituximab was conjugated with para isothiocyanato benzyl diethylene triamine penta acetic acid (p-NCS-Bz-DTPA) and subsequent radiolabeling with 99mTc was carried out via the 99mTc carbonyl synthon. The 99mTc labeled antibody conjugate exhibited >95% radiochemical purity after purification and retained good in vitro stability when studied up to 24Â h at room temperature. In vitro cell binding studies carried out in Raji cells expressing CD20 antigen validated the biological efficacy of the preparation.
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Authors
Usha Pandey, Mythili Kameswaran, Haladhar Dev Sarma, Grace Samuel,