A facile no-carrier-added one pot micro-molar scale radiosynthesis of 2-[14C]–uracil

A facile no-carrier-added one pot micro-molar scale radiolabelled synthesis of 2-[14C]–uracil from [14C]–urea and propiolic acid in the presence of polyphosphoric acid (PPA) with an yield of 48.33% and with radiochemical purity of 98% is reported in this paper.

Graphical abstractA facile one pot micro-molar scale radiolabelled synthesis of 2-[14C]–uracil from [14C]–urea and propiolic acid in the presence of polyphosphoric acid is reported.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The method adopted by us has not been reported so far for the 2-[14C]–uracil synthesis, as far as we know. ► Our aim to obtain a high specific activity product having high radiochemical purity met with success. ► To achieve the above, the radiosynthesis was carried out on micromolar scale. ► A radiochemical yield of 48.33% with radiochemical purity of more than 98% has been realized. ► The use of fuming sulphuric acid in the reaction was avoided to prevent any degradation of product.