An efficient synthesis of dopamine transporter tracer [18F]FECNT

A simple synthesis of the dopamine transporter ligand [18F]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2β-carbomethoxy-3β-(4-chlorophenyl)nortropane with [18F]2-fluoroethyl triflate ([18F]FEtOTf) at room temperature for 4 min provided [18F]FECNT in 84% decay corrected radiochemical yield. Since [18F]FEtOTf was prepared from [18F]2-fluoroethyl bromide that was isolated from its starting material, formation of unwanted side products and the amount of expensive precursor used could be greatly reduced. The overall radiochemical yields of [18F]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [18F]FECNT was 377.4 GBq/μmol (10.2 Ci/μmol).

► An efficient synthesis of dopamine transporter tracer [18F]FECNT is presented. ► Coupling using isolated labeling synthon reduces side products formation. ► Higher radiochemical yields and mild reaction conditons achieved. ► Very low amounts of expensive precursor used reducing the cost per synthesis. ► Suitable for routine production of [18F]FECNT.