| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1876322 | Applied Radiation and Isotopes | 2012 | 9 Pages |
Upgrades and optimisation achieved 160 μA total target current operation of a GE PETtrace cyclotron in dual target mode for the routine production of [18F]FDG for >2 years. Approximately 900 GBq of 18F− and >500 GBq of [18F]FDG can be produced routinely in a single production run, meeting the routine [18F]FDG requirements with our customer base and achieving economies of scale. Production of >1 TBq of 18F− in a single run was achieved. Reliability, saturation and synthesis yields were not adversely affected.
► Routine [18F]FDG production with a PETtrace cyclotron for >2 years at 160 μA. ► No deterioration in reliability and [18F]FDG yield at the higher beam currents. ► 500 GBq of [18F]FDG and >900 GBq of 18F− from a single production run. ► Sodium thiosulfate used to reduce radiolysis of high concentration [18F]FDG.
