Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876361 | Applied Radiation and Isotopes | 2012 | 5 Pages |
Successful use of electrochemical method to concentrate 99mTc obtained from a zirconium molybdate (Zr99Mo) gel generator is reported. The process consists of electrodeposition of the 99mTc in an oxalate bath on a small platinum electrode followed by recovery of 99mTc in a small volume of normal saline. The overall recovery of 99mTc was >90% with >99.99% radionuclidic purity and >99% radiochemical purity. The compatibility of the product in the preparation of 99mTc labeled formulations such as 99mTc-DMSA and 99mTc-EC was found to be satisfactory in terms of high labeling yields (>98%).
► Utility of electrochemical technique to concentrate 99mTc obtained from an expired Zr99Mo gel generator. ► Optimization of experimental conditions for quantitative deposition of 99mTc. ► Evaluation of quality features of the concentrated 99mTcO4− solution for radiopharmaceutical applications.