Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system

A fully automated and GMP compatible synthesis has been developed to reliably label the M1 receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [11C]methyl iodide afforded [11C]GSK1034702 in an estimated 10±3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [11C]GSK1034702 in a formulation suitable for human use.

► Preparation of [11C]GSK1034702 through a Stille cross-coupling reaction. ► Provision of the applicability of commercially available modules for the synthesis of non-standard PET tracers. ► Defining specification for heavy metals content in final dose product. ► Presenting results from validation of manufacturing process.