| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1876499 | Applied Radiation and Isotopes | 2011 | 5 Pages |
Abstract
Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. 99mTc-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of 99mTc-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in 99mTc-glucoheptonate uptake ratio was observed depending on the level of apoptosis. 99mTc-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Gamze Kocagozoglu, Fatma Yurt Lambrecht, Cumhur Gunduz, Musteyde YucebaÅ, Elif Bayrak Tabar, Aykut Ozgur, Tugce Balci,