Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876510 | Applied Radiation and Isotopes | 2011 | 5 Pages |
Abstract
Due to the specificity of expression of PSMA (prostate specific membrane antigen) particularly in prostate cancer cells (e.g. LNCaP), numerous PSMA ligands have been synthesized until now. In the current study, we synthesized DUPA-Pep having 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) linked via 8-aminooctanoic acid to two phenylalanine residues and chose 6-[18F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester [18F]FPy-TFP as a prosthetic group for coupling. [18F]FPy-DUPA-Pep was obtained in a radiochemical yield of 48±0.9% (decay uncorrected) within 50 min with a chemical purity of >98%.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Noeen Malik, Hans-Jürgen Machulla, Christoph Solbach, Gordon Winter, Sven N. Reske, Boris Zlatopolskiy,