| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1876531 | Applied Radiation and Isotopes | 2010 | 7 Pages |
Abstract
A novel zoledronic acid (ZL) derivative, 1-hydroxy-2-(2-ethyl-4-methyl-1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid (EMIDP), was prepared and labeled with 99mTc successfully in a high labeling yield and good stability in vitro. The preclinical pharmacological properties of 99mTc-EMIDP were investigated and compared with 99mTc-MDP and 99mTc-ZL. The studies of biodistribution in mice and SPECT bone imaging of the rabbit suggest that 99mTc-EMIDP has highly selective uptake in the skeletal system and rapid clearance in the soft tissues. The present findings indicate that 99mTc-EMIDP holds great potential for bone scintigraphy.
Keywords
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Jianguo Lin, Shineng Luo, Chuanqing Chen, Ling Qiu, Yan Wang, Wen Cheng, Wanzhong Ye, Yongmei Xia,