Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876547 | Applied Radiation and Isotopes | 2010 | 6 Pages |
Abstract
Automated radiosynthesis of [2-11C-carbonyl]dantrolene, the substrate of breast cancer resistance protein (BCRP/ABCG2), was performed for the first time through a multi-step/one-pot labeling sequence that started with ethyl 2-{2-[5-(4-nitrophenyl)furfurylidene]hydrazino}acetate and used [11C]phosgene as a labeling agent. After optimization of the automated synthesis conditions and parameters, [2-11C-carbonyl]dantrolene was obtained at a radiochemical yield of 34.0±8.4% (decay-corrected). The radiochemical purity was greater than 98% and the specific activity was 46.8±15.2 GBq/μmol at the end of the synthesis.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Yuuki Takada, Masanao Ogawa, Hisashi Suzuki, Toshimitsu Fukumura,